The Bounden of Isaac Rebirth is a archetype rogue-like game with bullet hell elements. The gameplay is solid, and the story baroque and deeply depressing. With multiple add-ons and expansions, it's go a large game that requires a corking level of skill and tact to trounce.

Fifty-fifty more stunning is the level of replayability with multiple character and item unlocks that, when combined with procedurally generated levels, enemies, and even randomized bosses, makes no two games the same. With all this randomization, it can be hard to reach all twenty endings of the game, only, for the completionists out at that place, hither's a guide on how to do precisely that. Or, for those without the fourth dimension, the gist of what happens in each ending!

Updated June 13th, 2022 by Ben Baker: With the recent release of Repentance, The Binding Of Isaac at present has 2 more endings and a bunch of rewards and unlocks. The already mammoth game has even more than replayability equally players swoop in to find out what has changed. To help those descending dorsum into the horrors of Isaac'southward mind, here are the additional endings and some of the perks that come with each ending.

23 Epilogue Ending

The Binding Of Isaac Mother Attacking Isaac

This catastrophe is adequately basic to achieve, simply defeat Mom and players volition earn this misleading ending. Isaac imagines his mother cornering him with a knife set up to sacrifice him to the voices in her head when The Bible falls from the shelf and kills her.

Unfortunately for Isaac, this turned out to be an imaginative story all in his head, and his female parent opens the door behind him to reveal a darker fate for the hero.

22 Ending 1 – Eden

Binding Of Isaac Eden

After defeating Mother's Center, Isaac falls into a mysterious chest that locks him inside. After a commotion, he breaks gratuitous of the breast in an explosion of light as the graphic symbol Eden with white hair that changes styles and bright glowing yellowish eyes.

Getting this ending volition unlock the playable character Eden. The actor must have an Eden tokens to play as this graphic symbol which are earned past defeating various bosses.

21 Ending 2 – Condom Cement

Binding Of Isaac Rubber Cement

Again, later defeating Mother'due south Heart, Isaac finds a bottle of condom cement inside the mysterious chest. For whatever reason, he slathers it on his eyes, turning them viscous white while gluing his eyelids open.

Getting this ending unlocks Condom Cement as a passive item that can be constitute. It essentially causes tears to bounciness off all objects potentially striking enemies more one time.

twenty Ending three – Noose

The Binding Of Isaac Noose

Another ending achieved after defeating Female parent's Heart, Isaac encounters the mysterious chest again and finds a length of rope within. The histrion is then treated to one of the darkest endings available in the game. That's really saying something, as this game can exist particularly dreary in places.

This ending will unlock the passive item Transcendence. This enables Isaac to permanently wing.

19 Ending 4 – Wire Glaze Hanger

The Binding Of Isaac Wire Coat Hanger

A randomized catastrophe after chirapsia Mother's Center, Isaac opens the mysterious chest to detect a Wire Coat Hanger which he promptly shoves through his caput.

This catastrophe volition unlock the Wire Glaze Hanger passive item. This boosts tear attack force past .seven when picked upwardly.

18 Ending v – Everything Is Terrible

The Binding Of Isaac Opening Chest

Subsequently defeating Mother's Heart, Isaac opens the mysterious chest to be assaulted by his female parent'southward large arm. After punching him, the arm grabs him and yanks him into the chest as Mother cackles somewhere out of sight.

This unlocks the mode Everything Is Terrible which makes the game significantly more challenging.

17 Catastrophe vi – Ipecac

The Binding Of Isaac Ipecac

Another piece of cake ending to attain by defeating Mother'south Heart, Isaac opens the chest to find something out of view. He steps away from the breast and becomes ill earlier turning to vomit into the chest, causing an explosion.

This ending volition unlock the passive detail Ipecac. Ipecac replaces tears with projectiles that are explosive and poisonous.

16 Ending 7 – Experimental Treatment

The Binding Of Isaac Experimental Treatment

I of the more disturbing endings later chirapsia Mother'southward Middle, Isaac finds a yellow syringe in the mysterious breast and presumably injects himself with information technology. Subsequently Isaac is shown incredibly deformed, slumped on the ground sporting a cartoonishly distorted face.

This ending introduces the passive particular Experimental Treatment to the game. When used it will randomly increase and decrease Isaac's stats.

xv Ending 8 – Quarter

The Binding Of Isaac Quarter

Beating Mother'south Heart yields this semi-happy ending where Isaac finds a Quarter in the mysterious chest with no disturbing or nighttime side furnishings. Information technology's considered the happiest possible ending in the game.

With this catastrophe players volition have access to A Quarter. When institute in the game information technology immediately gives Isaac 25 cents.

14 Catastrophe ix – Dr. Fetus

The Binding Of Isaac Dr. Fetus

Another ending resulting from the devastation of Mother's Heart, Isaac encounters the mysterious chest and finds a glass jar with a fetus inside. The thespian then sees Isaac wearing a pinnacle lid and monocle, supposedly having become Dr. Fetus. This ending is a reference to Super Meat Male child, some other of indie game developer Edmund McMillen's creations.

If players get this ending information technology will unlock the passive item Dr. Fetus. Dr. Fetus replaces tears with bombs that have a very brusque detonation fourth dimension and bargain three times the impairment of a tear.

13 Catastrophe 10 - ???

The Binding Of Isaac Blue Boy

This nighttime catastrophe is a upshot of defeating Female parent's Heart. Hither Isaac opens the mysterious breast to find the unsettling ??? grapheme inside, a young boy with blue skin and crossed out eyes signifying that he'southward dead. The body lifts upwardly and startles Isaac, who plummets into a spiraling void.

This  catastrophe will unlock the playable character ??? as known as Blue Baby. ??? tin only accept Soul Hearts or Blackness Hearts and starts with the particular The Poop.

12 Ending 11 – Information technology Lives

The Binding Of Isaac It Lives

This weird ending is the last i that can be achieved later on defeating Mother's Heart. Isaac opens the mysterious chest and is surprised past what'south inside, presumably nothing. And so all of a sudden It Lives, a variation of Mother's Center with an eerie face embedded in the organ, pops upwards behind him and growls.

This ending unlocks It Lives as a boss, which makes other endings much easier to attain, but is a harder boss to kill.

11 Ending 12 – Unlike Lives

Crying Isaac in The Binding of Isaac

This ending requires the player to vanquish Satan on the last floor Sheol which is unlocked in i of four ways; a trapdoor will randomly spawn to Sheol after a actor defeats Female parent's Middle, if the player has unlocked Information technology Lives the trapdoor volition e'er spawn, the item Nosotros Need To Go Deeper tin can be used on the Womb Ii level to open a trapdoor, and the Joker tin can be used in Womb 2 to create a Devil Deal room that has a trapdoor leading to Sheol.

Upon opening the mysterious chest, Isaac rapidly changes into the different characters. After going through them all, he returns to normal in his own room and clambers inside the chest.

Depending on which character the thespian is using when defeating Satan volition unlock different items. Here is a list:

  • Isaac - Mom'due south Knife
  • Maggy - The Guardian Angel
  • Judas - The Monster Manual
  • Cain - The Bomb Purse
  • Eve - The Demon Baby
  • ??? - Forget Me At present
  • Samson - Blood Rights

10 Catastrophe thirteen – Evil Within

The Binding Of Isaac Mirror

To accomplish this eerie ending, players must defeat the boss Isaac, a crying version of the main character found on the Cathedral floor. To get to the Cathedral, player's must randomly spawn an Angel Room after defeating Mother'southward Heart or get a guaranteed doorway after defeating Information technology Lives.

Isaac is seen reading a Bible before facing a mirror version of himself that is black skinned with reddish eyes, symbolic of the wickedness he feels is inside him.

There are a staggering number of things to unlock via this ending. Information technology depends on which character is used, how many times Isaac is defeated, which other bosses have been defeated, and varying combinations thereof. It would honestly have a guide all its ain.

9 Catastrophe 14 – Pictures Tell A Chiliad Words

The Binding Of Isaac Picture

This ending requires the players to beat The Chest level, which is accessible via three dissimilar methods. The first requires the role player to bear upon the chest left backside by the boss Isaac while The Polaroid item is equipped, the other is to utilize the telepills on the Cathedral floor to enter the I AM Fault room, and the final method can be institute by entering a Black Market on the Cathedral floor and walking into the beam of light establish at that place.

This ending shows a series of pictures depicting a happy family unit earlier the dad is seen leaving, the mother goes insane, and Isaac succumbs to the evil within him.

Completing this catastrophe usually will unlock the Angels minibosses. Getting this ending without taking whatever damage will unlock Dead Boy.

8 Catastrophe 15 – Missing

The Binding Of Isaac Missing

Beating the Nighttime Room yields this ending, and there'southward a number of ways to access it. Player's can beat Satan five times, so touch his chest while holding The Negative particular. They can likewise get to it through the I AM Fault room, by killing Uriel and Gabriel and and then using a sacrifice room, or by inbound a trapdoor within a Black Market place.

The cutscene shows a missing poster for Isaac with his mother searching for him in the background.

This catastrophe unlocks the Missing Poster Trinket. It'south not one of the most useful trinkets out there, but it's something to survive the nightmares.

7 Ending xvi – The Demon Takes Over

The Binding Of Isaac Crying In Chest

This ending requires the player to defeat Mega Satan, which has some requirements to even spawn. The play must take defeated either ??? or the Lamb and collect all central pieces or have Dad's Key. Doing this opens the Golden Key door where stepping on a pentagram spawns Mega Satan.

This catastrophe shows Isaac curled up in the chest breathing heavily as he'due south slowly taken over by a smiling demon.

Similar to defeating Isaac there are a massive number of things to unlock by defeating the Mega Satan as different characters. It too changes based on which DLC are active during the playthrough.

6 Catastrophe 17 – Purgatory

The Binding Of Isaac Remains

To unlock this catastrophe, players must defeat the boss Hush found in the Blue Womb that is accessible but after defeating Female parent's Center for the tenth time, which will happen naturally given how many times Mother'due south Heart must be defeated to unlock other endings.

This catastrophe is similar to Catastrophe xv in that it starts with the missing poster. However, instead of fading to black, we see Isaac'due south mother finding his dusty remains in the breast. It and then cuts to an empty world with Isaac appearing out of a red chest earlier a dark winged effigy appears behind him.

Once once again the things unlocked with this ending depend on the character used and which DLCs are active.

5 Catastrophe 18 – Greed

The Binding Of Isaac Cave

To get this ending, the role player must be playing Greed Mode which alters the game in varying ways. Player's must defeat the final boss known as Ultra Greed.

In this cutscene, Isaac is shown to have been trapped in a cave subsequently the entrance is caved in. Later, his corpse is seen in the aforementioned position as the Shopkeeper before suddenly smiling.

Defeating Ultra Greed will unlock diverse items depending on which of the dozens of character options are used.

4 Ending nineteen – Greedier

The Binding Of Isaac Shopkeeper

This ending requires the thespian to crush the game first on Greed Fashion and and then the subsequent Greedier Way which makes the game much harder than it previously was.

The cutscene is identical to Ending xviii with the notable exception that, after the Shopkeeper corpse smiles, his head falls off, and his neck spews out a mass of flies.

In that location are even more unlocks in The Greedier ending than Greed ending.

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