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Where Can I Donate My Embryos for Research

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Multicellular diploid eukaryote in its earliest stage of development

Embryo
Embryo 7 weeks after conception.jpg

A male human embryo, seven weeks old
or nine weeks' gestational age
Identifiers
TE E1.0.2.6.4.0.5
Anatomical terminology

[edit on Wikidata]

An embryo is the early stage of development of a multicellular organism. In general, in organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization and continues through the formation of body structures, such as tissues and organs. Each embryo starts development as a zygote, a single cell resulting from the fusion of gametes (i.e. the process of fertilization which is the fusion of a female egg cell and a male sperm cell). In the first stages of embryonic development, a single-celled zygote undergoes many rapid cell divisions, called cleavage, to form a blastula, which looks similar to a ball of cells. Next, the cells in a blastula-stage embryo start rearranging themselves into layers in a process called gastrulation. These layers will each give rise to different parts of the developing multicellular organism, such as the nervous system, connective tissue, and organs.

A newly developing human is typically referred to as an embryo until the ninth week after conception, when it is then referred to as a fetus. In other multicellular organisms, the word "embryo" can be used more broadly to any early developmental or life cycle stage prior to birth or hatching.

Etymology [edit]

First attested in English in the mid-14c., the word embryon derives from Medieval Latin embryo, itself from Greek ἔμβρυον (embruon), lit. "young one",[1] which is the neuter of ἔμβρυος (embruos), lit. "growing in",[2] from ἐν (en), "in"[3] and βρύω (bruō), "swell, be full";[4] the proper Latinized form of the Greek term would be embryum.

Development [edit]

Animal embryos [edit]

Embryonic development of salamander, circa the 1920s

Embryos (and one tadpole) of the wrinkled frog (Rana rugosa)

In animals, fertilization begins the process of embryonic development with the creation of a zygote, a single cell resulting from the fusion of gametes (e.g. egg and sperm).[5] The development of a zygote into a multicellular embryo proceeds through a series of recognizable stages, often divided into cleavage, blastula, gastrulation, and organogenesis.[6]

Cleavage is the period of rapid mitotic cell divisions that occur after fertilization. During cleavage, the overall size of the embryo does not change, but the size of individual cells decrease rapidly as they divide to increase the total number of cells.[7] Cleavage results in a blastula.[6]

Depending on the species, a blastula stage embryo can appear as a ball of cells on top of yolk, or as a hollow sphere of cells surrounding a middle cavity.[8] The embryo's cells continue to divide and increase in number, while molecules within the cells such as RNAs and proteins actively promote key developmental processes such as gene expression, cell fate specification, and polarity.[9]

Gastrulation is the next phase of embryonic development, and involves the development of two or more layers of cells (germinal layers). Animals that form two layers (such as Cnidaria) are called diploblastic, and those that form three (most other animals, from flatworms to humans) are called triploblastic. During gastrulation of triploblastic animals, the three germinal layers that form are called the ectoderm, mesoderm, and endoderm.[8] All tissues and organs of a mature animal can trace their origin back to one of these layers.[10] For example, the ectoderm will give rise to the skin epidermis and the nervous system,[11] the mesoderm will give rise to the vascular system, muscles, bone, and connective tissues,[12] and the endoderm will give rise to organs of the digestive system and epithelium of the digestive system and respiratory system.[13] [14] Many visible changes in embryonic structure happen throughout gastrulation as the cells that make up the different germ layers migrate and cause the previously round embryo to fold or invaginate into a cup-like appearance.[8]

Past gastrulation, an embryo continues to develop into a mature multicellular organism by forming structures necessary for life outside of the womb or egg. As the name suggests, organogenesis is the stage of embryonic development when organs form. During organogenesis, molecular and cellular interactions prompt certain populations of cells from the different germ layers to differentiate into organ-specific cell types.[15] For example, in neurogenesis, a subpopulation of cells from the ectoderm segregate from other cells and further specialize to become the brain, spinal cord, or peripheral nerves.[16]

The embryonic period varies from species to species. In human development, the term fetus is used instead of embryo after the ninth week after conception,[17] whereas in zebrafish, embryonic development is considered finished when a bone called the cleithrum becomes visible.[18] In animals that hatch from an egg, such as birds, a young animal is typically no longer referred to as an embryo once it has hatched. In vivaparous animals (animals whose offspring spend at least some time developing within a parent's body), the offspring is typically referred to as an embryo while inside of the parent, and is no longer considered an embryo after birth or exit from the parent. However, the extent of development and growth accomplished while inside of an egg or parent varies significantly from species to species, so much so that the processes that take place after hatching or birth in one species may take place well before those events in another. Therefore, according to one textbook, it is common for scientists interpret the scope of embryology broadly as the study of the development of animals.[8]

Plant embryos [edit]

The inside of a Ginkgo seed, showing the embryo

Flowering plants (angiosperms) create embryos after the fertilization of a haploid ovule by pollen. The DNA from the ovule and pollen combine to form a diploid, single-cell zygote that will develop into an embryo.[19] The zygote, which will divide multiple times as it progresses throughout embryonic development, is one part of a seed. Other seed components include the endosperm, which is tissue rich in nutrients that will help support the growing plant embryo, and the seed coat, which is a protective outer covering. The first cell division of a zygote is asymmetric, resulting in an embryo with one small cell (the apical cell) and one large cell (the basal cell).[20] The small, apical cell will eventually give rise to most of the structures of the mature plant, such as the stem, leaves, and roots.[21] The larger basal cell will give rise to the suspensor, which connects the embryo to the endosperm so that nutrients can pass between them.[20] The plant embryo cells continue to divide and progress through developmental stages named for their general appearance: globular, heart, and torpedo. In the globular stage, three basic tissue types (dermal, ground, and vascular) can be recognized.[20] The dermal tissue will give rise to the epidermis or outer covering of a plant,[22] ground tissue will give rise to inner plant material that functions in photosynthesis, resource storage, and physical support,[23] and vascular tissue will give rise to connective tissue like the xylem and phloem that transport fluid, nutrients, and minerals throughout the plant.[24] In heart stage, one or two cotyledons (embryonic leaves) will form. Meristems (centers of stem cell activity) develop during the torpedo stage, and will eventually produce many of the mature tissues of the adult plant throughout its life.[20] At the end of embryonic growth, the seed will usually go dormant until germination.[25] Once the embryo begins to germinate (grow out from the seed) and forms its first true leaf, it is called a seedling or plantlet.[26]

Plants that produce spores instead of seeds, like bryophytes and ferns, also produce embryos. In these plants, the embryo begins its existence attached to the inside of the archegonium on a parental gametophyte from which the egg cell was generated.[27] The inner wall of the archegonium lies in close contact with the "foot" of the developing embryo; this "foot" consists of a bulbous mass of cells at the base of the embryo which may receive nutrition from its parent gametophyte.[28] The structure and development of the rest of the embryo varies by group of plants.[29]

Since all land plants create embryos, they are collectively referred to as embryophytes (or by their scientific name, Embryophyta). This, along with other characteristics, distinguishes land plants from other types of plants, such as algae, which do not produce embryos.[30]

Research and technology [edit]

Biological processes [edit]

Embryos from numerous plant and animal species are studied in biological research laboratories across the world to learn about topics such as stem cells,[31] evolution and development,[32] cell division,[33] and gene expression.[34] Examples of scientific discoveries made while studying embryos that were awarded the Nobel Prize in Physiology or Medicine include the Spemann-Mangold organizer, a group of cells originally discovered in amphibian embryos that give rise to neural tissues,[35] and genes that give rise to body segments discovered in Drosophila fly embryos by Christiane Nüsslein-Volhard and Eric Wieschaus.[36]

Assisted reproductive technology [edit]

Creating and/or manipulating embryos via assisted reproductive technology (ART) is used for addressing fertility concerns in humans and other animals, and for selective breeding in agricultural species. Between the years 1987 and 2015, ART techniques including in vitro fertilization (IVF) were responsible for an estimated 1 million human births in the United States alone.[37] Other clinical technologies include preimplantation genetic diagnosis (PGD), which can identify certain serious genetic abnormalities, such as aneuploidy, prior to selecting embryos for use in IVF.[38] Some have proposed (or even attempted - see He Jiankui affair) genetic editing of human embryos via CRISPR-Cas9 as a potential avenue for preventing disease;[39] however, this has been met with widespread condemnation from the scientific community.[40] [41]

ART techniques are also used to improve the profitability of agricultural animal species such as cows and pigs by enabling selective breeding for desired traits and/or to increase numbers of offspring.[42] For example, when allowed to breed naturally, cows typically produce one calf per year, whereas IVF increases offspring yield to 9-12 calves per year.[43] IVF and other ART techniques, including cloning via interspecies somatic cell nuclear transfer (iSCNT),[44] are also used in attempts to increase the numbers of endangered or vulnerable species, such as Northern white rhinos,[45] cheetahs,[46] and sturgeons.[47]

Cryoconservation of plant and animal biodiversity [edit]

Cryoconservation of genetic resources involves collecting and storing the reproductive materials, such as embryos, seeds, or gametes, from animal or plant species at low temperatures in order to preserve them for future use.[48] Some large-scale animal species cryoconservation efforts include "frozen zoos" in various places around the world, including in the UK's Frozen Ark,[49] the Breeding Centre for Endangered Arabian Wildlife (BCEAW) in the United Arab Emirates,[50] and the San Diego Zoo Institute for Conservation in the United States.[51] [52] As of 2018, there were approximately 1,700 seed banks used to store and protect plant biodiversity, particularly in the event of mass extinction or other global emergencies.[53] The Svalbard Global Seed Vault in Norway maintains the largest collection of plant reproductive tissue, with more than a million samples stored at −18 °C (0 °F).[54]

Fossilized embryos [edit]

Fossilized animal embryos are known from the Precambrian, and are found in great numbers during the Cambrian period. Even fossilized dinosaur embryos have been discovered.[55]

See also [edit]

  • Embryo loss
  • Plant embryogenesis
  • Pregnancy
  • Prenatal development
  • In vitro fertilisation
  • Proembryo
  • Miscarriage
  • Abortion

Notes [edit]

  1. ^ ἔμβρυον Archived 2013-05-31 at the Wayback Machine, Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus
  2. ^ ἔμβρυος Archived 2013-05-31 at the Wayback Machine, Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus
  3. ^ ἐν Archived 2013-05-31 at the Wayback Machine, Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus
  4. ^ βρύω Archived 2013-05-31 at the Wayback Machine, Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus
  5. ^ "24.6. Fertilization and Early Embryonic Development – Concepts of Biology – 1st Canadian Edition". opentextbc.ca . Retrieved 2019-10-30 .
  6. ^ a b Gilbert, Scott F. (2000). "The Circle of Life: The Stages of Animal Development". Developmental Biology. 6th Edition.
  7. ^ "DevBio 11e". 11e.devbio.com . Retrieved 2019-11-07 .
  8. ^ a b c d Balinsky, Boris Ivan (1975). An Introduction to Embryology (Fourth ed.). W.B. Saunders Company. ISBN0-7216-1518-X.
  9. ^ Heasman, Janet (2006-04-01). "Patterning the early Xenopus embryo". Development. 133 (7): 1205–1217. doi:10.1242/dev.02304. ISSN 0950-1991. PMID 16527985.
  10. ^ Favarolo, María Belén; López, Silvia L. (2018-12-01). "Notch signaling in the division of germ layers in bilaterian embryos". Mechanisms of Development. 154: 122–144. doi:10.1016/j.mod.2018.06.005. ISSN 0925-4773. PMID 29940277.
  11. ^ "Ectoderm | The Embryo Project Encyclopedia". embryo.asu.edu . Retrieved 2019-11-07 .
  12. ^ "Mesoderm | The Embryo Project Encyclopedia". embryo.asu.edu . Retrieved 2019-11-07 .
  13. ^ Zorn, Aaron M.; Wells, James M. (2009). "Vertebrate Endoderm Development and Organ Formation". Annual Review of Cell and Developmental Biology. 25: 221–251. doi:10.1146/annurev.cellbio.042308.113344. ISSN 1081-0706. PMC2861293. PMID 19575677.
  14. ^ Nowotschin, Sonja; Hadjantonakis, Anna-Katerina; Campbell, Kyra (2019-06-01). "The endoderm: a divergent cell lineage with many commonalities". Development. 146 (11): dev150920. doi:10.1242/dev.150920. ISSN 0950-1991. PMC6589075. PMID 31160415.
  15. ^ "Process of Eukaryotic Embryonic Development | The Embryo Project Encyclopedia". embryo.asu.edu . Retrieved 2019-11-07 .
  16. ^ Hartenstein, Volker; Stollewerk, Angelika (2015-02-23). "The Evolution of Early Neurogenesis". Developmental Cell. 32 (4): 390–407. doi:10.1016/j.devcel.2015.02.004. ISSN 1534-5807. PMC5987553. PMID 25710527.
  17. ^ "Embryo vs. Fetus: The First 27 Weeks of Pregnancy". MedicineNet . Retrieved 2019-11-07 .
  18. ^ Kimmel, Charles B.; Ballard, William W.; Kimmel, Seth R.; Ullmann, Bonnie; Schilling, Thomas F. (1995). "Stages of embryonic development of the zebrafish". Developmental Dynamics. 203 (3): 253–310. doi:10.1002/aja.1002030302. ISSN 1097-0177. PMID 8589427. S2CID 19327966.
  19. ^ "seed | Form, Function, Dispersal, & Germination". Encyclopedia Britannica . Retrieved 2019-11-09 .
  20. ^ a b c d "Chapter 12A. Plant Development". biology.kenyon.edu . Retrieved 2019-11-09 .
  21. ^ Hove, Colette A. ten; Lu, Kuan-Ju; Weijers, Dolf (2015-02-01). "Building a plant: cell fate specification in the early Arabidopsis embryo". Development. 142 (3): 420–430. doi:10.1242/dev.111500. ISSN 0950-1991. PMID 25605778.
  22. ^ "| CK-12 Foundation". www.ck12.org . Retrieved 2019-11-09 .
  23. ^ "GLOSSARY G". www2.estrellamountain.edu . Retrieved 2019-11-09 .
  24. ^ "Vascular Tissue". Biology Dictionary. 2018-05-21. Retrieved 2019-11-09 .
  25. ^ Penfield, Steven (2017-09-11). "Seed dormancy and germination". Current Biology. 27 (17): R874–R878. doi:10.1016/j.cub.2017.05.050. ISSN 0960-9822. PMID 28898656.
  26. ^ "Germination and Seedling Emergence". Forage Information System. 2016-03-28. Retrieved 2019-11-09 .
  27. ^ "Life Cycle - in a nutshell - bryophyte". www.anbg.gov.au . Retrieved 2019-11-14 .
  28. ^ "Plant development - Nutritional dependence of the embryo". Encyclopedia Britannica . Retrieved 2019-11-14 .
  29. ^ "Bryophytes – Biology 2e". opentextbc.ca . Retrieved 2019-11-14 .
  30. ^ "What are seaweeds?". formosa.ntm.gov.tw . Retrieved 2019-11-09 .
  31. ^ Mummery, Christine; van de Stolpe, Anja; Roelen, Bernard A. J.; Clevers, Hans, eds. (2014-01-01), "Chapter 4 - Of Mice and Men: The History of Embryonic Stem Cells", Stem Cells (Second Edition), Academic Press, pp. 69–100, ISBN9780124115514 , retrieved 2019-11-14
  32. ^ Martín-Durán, José M.; Monjo, Francisco; Romero, Rafael (2012). "Planarian embryology in the era of comparative developmental biology". The International Journal of Developmental Biology. 56 (1–3): 39–48. doi:10.1387/ijdb.113442jm. ISSN 1696-3547. PMID 22450993.
  33. ^ Kumar, Megha; Pushpa, Kumari; Mylavarapu, Sivaram V. S. (July 2015). "Splitting the cell, building the organism: Mechanisms of cell division in metazoan embryos". IUBMB Life. 67 (7): 575–587. doi:10.1002/iub.1404. ISSN 1521-6551. PMC5937677. PMID 26173082.
  34. ^ Jukam, David; Shariati, S. Ali M.; Skotheim, Jan M. (2017-08-21). "Zygotic Genome Activation in Vertebrates". Developmental Cell. 42 (4): 316–332. doi:10.1016/j.devcel.2017.07.026. ISSN 1878-1551. PMC5714289. PMID 28829942.
  35. ^ "Spemann-Mangold Organizer | The Embryo Project Encyclopedia". embryo.asu.edu . Retrieved 2019-11-14 .
  36. ^ "The Nobel Prize in Physiology or Medicine 1995". NobelPrize.org . Retrieved 2019-11-14 .
  37. ^ "IVF by the Numbers – Penn Medicine". www.pennmedicine.org . Retrieved 2020-04-15 .
  38. ^ Basille, Claire; Frydman, René; El Aly, Abdelwahab; Hesters, Laetitia; Fanchin, Renato; Tachdjian, Gérard; Steffann, Julie; LeLorc'h, Marc; Achour-Frydman, Nelly (July 2009). "Preimplantation genetic diagnosis: state of the art". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 145 (1): 9–13. doi:10.1016/j.ejogrb.2009.04.004. ISSN 1872-7654. PMID 19411132.
  39. ^ "New U.S. Experiments Aim To Create Gene-Edited Human Embryos". NPR.org . Retrieved 2020-04-15 .
  40. ^ Cyranoski, David; Ledford, Heidi (2018-11-26). "Genome-edited baby claim provokes international outcry". Nature. 563 (7733): 607–608. Bibcode:2018Natur.563..607C. doi:10.1038/d41586-018-07545-0. PMID 30482929. S2CID 53768039.
  41. ^ "Experts Are Calling for a Ban on Gene Editing of Human Embryos. Here's Why They're Worried". Time . Retrieved 2020-04-15 .
  42. ^ Blondin, P. (January 2016). "Logistics of large scale commercial IVF embryo production". Reproduction, Fertility, and Development. 29 (1): 32–36. doi:10.1071/RD16317. ISSN 1031-3613. PMID 28278791.
  43. ^ "Agriculture for Impact Embryo Transfer". Retrieved 2020-04-15 .
  44. ^ Fletcher, Amy Lynn (2014). "Bio-Interventions: Cloning Endangered Species as Wildlife Conservation". In Fletcher, Amy Lynn (ed.). Mendel's Ark. Mendel's Ark: Biotechnology and the Future of Extinction. Springer Netherlands. pp. 49–66. doi:10.1007/978-94-017-9121-2_4. ISBN978-94-017-9121-2.
  45. ^ Sample, Ian (2019-09-11). "Scientists use IVF procedures to help save near-extinct rhinos". The Guardian. ISSN 0261-3077. Retrieved 2020-04-15 .
  46. ^ Lee, Alicia. "Two cheetah cubs were born for the first time by IVF. The breakthrough offers hope for the threatened species". CNN . Retrieved 2020-04-15 .
  47. ^ Fatira, Effrosyni; Havelka, Miloš; Labbé, Catherine; Depincé, Alexandra; Iegorova, Viktoriia; Pšenička, Martin; Saito, Taiju (2018-04-16). "Application of interspecific Somatic Cell Nuclear Transfer (iSCNT) in sturgeons and an unexpectedly produced gynogenetic sterlet with homozygous quadruple haploid". Scientific Reports. 8 (1): 5997. Bibcode:2018NatSR...8.5997F. doi:10.1038/s41598-018-24376-1. ISSN 2045-2322. PMC5902484. PMID 29662093.
  48. ^ "The Role of Biotechnology in Exploring and Protecting Agricultural Genetic Resources". www.fao.org . Retrieved 2020-04-15 .
  49. ^ "Frozen Ark".
  50. ^ "Breeding Centre for Endangered Arabian Wildlife". www.bceaw.ae . Retrieved 2020-04-15 .
  51. ^ "Frozen Zoo®". San Diego Zoo Institute for Conservation Research. 2016-01-26. Retrieved 2020-04-15 .
  52. ^ "San Diego's Frozen Zoo Offers Hope for Endangered Species Around the World". Smithsonian Magazine . Retrieved 2020-04-15 .
  53. ^ "A vast crypt was built to protect humans from the apocalypse. But doomsday might already be here". The Independent. 2018-03-04. Retrieved 2020-04-15 .
  54. ^ "Svalbard Global Seed Vault". Crop Trust . Retrieved 2020-04-15 .
  55. ^ Morelle, Rebecca. "Dinosaur embryo fossils reveal life inside the egg". BBC News. Archived from the original on 24 September 2015. Retrieved 8 August 2015.

External links [edit]

Wikimedia Commons has media related to Embryos.
Wikiquote has quotations related to: Embryo
  • UNSW Embryology - Educational website
  • A Comparative Embryology Gallery
  • 4-H Embryology, University of Nebraska-Lincoln Extension in Lancaster County
  • Video with embryo of a small-spotted catshark inside the egg on YouTube

Where Can I Donate My Embryos for Research

Source: https://en.wikipedia.org/wiki/Embryo

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